Formulation of Extended-Release Metformin Hydrochloride Matrix Tablets
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چکیده
منابع مشابه
GLUCOPHAGE (metformin hydrochloride) Tablets GLUCOPHAGE XR (metformin hydrochloride) Extended-Release Tablets
DESCRIPTION GLUCOPHAGE (metformin hydrochloride) Tablets and GLUCOPHAGE XR (metformin hydrochloride) Extended-Release Tablets are oral antihyperglycemic drugs used in the management of type 2 diabetes. Metformin hydrochloride (N,N-dimethylimidodicarbonimidic diamide hydrochloride) is not chemically or pharmacologically related to any other classes of oral antihyperglycemic agents. The structura...
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The objective of the present investigation was to study the effect of critical formulation parameters affecting release of isoxsuprine hydrochloride from matrix tablets using combination of polyethylene oxide (PEO) and dicalcium phosphate (DCP). The powder blend consisting of drug and excipients was analyzed for angle of repose, Carr’s index and Hausner’s ratio. The tablets were prepared by dir...
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Metformin HCL, the only available biguanide, remains the first line drug therapy for patients with Type 2 diabetes mellitus acts by decreasing hepatic glucose output and peripheral insulin resistance. It has relatively short plasma half life, low absolute bioavailability. The overall objective of the present work was to develop an oral sustained release metformin tablet prepared by direct compr...
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ژورنال
عنوان ژورنال: Tropical Journal of Pharmaceutical Research
سال: 2011
ISSN: 1596-9827,1596-5996
DOI: 10.4314/tjpr.v10i4.2